Multifunctional nanomaterials for the theranostics of diseases, including the application of functional carbonaceous nanomaterials in PDT and PTT, and drug-deliver system for targeting imaging and therapy.
Photodynamic therapy (PDT) is a light-activated modality for treatment of cancers and other diseases. It has been proved to be an effective way to target cell death with minor damage to surrounding healthy cells. Mechanism as follows.
Polymeric micelles as its good biocompatible, cheap raw materials, biodegradable and simple synthetic modification are widespread concern. The amphiphilic modification to the skeleton of natural polymers (chitosan, cellulose, etc.), and form a hydrophilic group as the shell in an aqueous solution. Trough coating anti-cancer drug molecule, fluorescent molecules, and superparamagnetic iron oxide nanoparticles (SPIO), achieve the goals to integrate diagnosis (fluorescence imaging or MRI imaging) with therapeutic (anticancer drugs) tumor tissue.
