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BiochemistryFullerenes and endohedral fullerenes have attracted considerable attention in the science field since their discovery in 1985. Especially, the novel physicochemical properties along with the exotic nanostructures make them an appealing subject in medicinal chemistry. The smart modification on the unique carbon cage further endows them abundant functionality. For example, in fullerene family, nano prince C60, can be exploited in various medical fields due to the appealing photo, electrochemical and physical properties, such as HIV protease inhibitor, radical scavenger and antioxidant, photosensitizer , gene and drug deliver carrier, and so on. Once other functional atoms or clusters are ncapsulated inside the carbon cage, the resulting endohedral fullerenes will exhibit the unique properties of both endoclusters and carbon cage. For example, paramagnetic gadolinium encapsulated endofullerenes can work as high efficient magnetic resonance imaging contrast agent with low toxicity, radiolabelled 166Ho encapsulated endofullerenes can work as radiotracer. |
